MCL-1/BCL-2-IN-3

Modify Date: 2025-08-28 00:27:12

MCL-1/BCL-2-IN-3 Structure
MCL-1/BCL-2-IN-3 structure
Common Name MCL-1/BCL-2-IN-3
CAS Number 2163793-55-1 Molecular Weight 569.47
Density N/A Boiling Point N/A
Molecular Formula C27H25BrN2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MCL-1/BCL-2-IN-3


MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively[1].

 Names

Name MCL-1/BCL-2-IN-3

 MCL-1/BCL-2-IN-3 Biological Activity

Description MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively[1].
Related Catalog
References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

 Chemical & Physical Properties

Molecular Formula C27H25BrN2O5S
Molecular Weight 569.47
InChIKey HZZXWFWVQWMGAR-UHFFFAOYSA-N
SMILES COC(=O)CCCCC(=O)NCCN1C(=O)c2cccc3c(Sc4ccc(Br)cc4)ccc(c23)C1=O
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