2490542-33-9
2490542-33-9 structure
- Name: Bcl-2-IN-9
- Chemical Name: Bcl-2-IN-9
- CAS Number: 2490542-33-9
- Molecular Formula: C27H31N7O3S
- Molecular Weight: 533.65
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-16 18:59:22
- Modify Date: 2024-01-11 19:09:57
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Bcl-2-IN-9 is a novel proapoptotic Bcl-2 inhibitor with IC50 value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells[1].
| Name | Bcl-2-IN-9 |
|---|
| Description | Bcl-2-IN-9 is a novel proapoptotic Bcl-2 inhibitor with IC50 value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells[1]. |
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| Related Catalog | |
| Target |
Bcl-2:2.9 μM (IC50, [1]) |
| In Vitro | Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) inhibits HL-60 cells in vitro[1]. Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) shows low cytotoxic effects against WI-38 cells with cell viability of 91%[1]. Bcl-2-IN-9 (compound 6e) (10 μM, 48 hours) displays a high selectivity against leukemia cells[1]. Bcl-2-IN-9 (compound 6e) (10 μM) mediates apoptotic by down-regulating expression of Bcl-2 and causing chromatin compaction and nuclear fragmentation[1]. Cell Viability Assay[1] Cell Line: HL-60 cells Concentration: 1, 10, 20, 40 μM Incubation Time: 48 hours Result: Surpressed cell growth and viability to 28.9%. Cell Cytotoxicity Assay[1] Cell Line: WT-38 cells Concentration: 10 μM Incubation Time: 48 hours Result: Low cytotoxic effects. Apoptosis Analysis[1] Cell Line: HL-60 cells Concentration: 1, 10, 20, 40 μM Incubation Time: 48 hours Result: Caused chromatin compaction and nuclear fragmentation. |
| References |
| Molecular Formula | C27H31N7O3S |
|---|---|
| Molecular Weight | 533.65 |