Bcl-2-IN-4

Names

[ CAS No. ]:
2703134-40-9

[ Name ]:
Bcl-2-IN-4

Biological Activity

[Description]:

Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2)[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[Target]

Bcl-2:1.5 nM (IC50)

Bcl-xL:411 nM (IC50)


[References]

[1]. Hongjian Wang, et al. Benzo five-membered cyclic compound. WO2021180040A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C46H50ClN9O7S

[ Molecular Weight ]:
908.46

Related Compounds