Bcl-2-IN-5

Names

[ CAS No. ]:
2728752-20-1

[ Name ]:
Bcl-2-IN-5

Biological Activity

[Description]:

Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155)[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[Target]

Bcl-2:0.12 nM (IC50)

Bcl-2 D103Y:0.14 nM (IC50)

Bcl-2 G101V:0.22 nM (IC50)


[References]

[1]. Hai Xue, et al. Bcl-2 inhibitor. WO2021208963A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C55H63FN8O8S

[ Molecular Weight ]:
1015.20

Related Compounds