MAK683-CH2CH2COOH
Modify Date: 2025-08-26 16:56:03
MAK683-CH2CH2COOH structure
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Common Name | MAK683-CH2CH2COOH | ||
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| CAS Number | 2639882-68-9 | Molecular Weight | 448.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H21FN6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MAK683-CH2CH2COOHMAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615)[1]. |
| Name | MAK683-CH2CH2COOH |
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| Description | MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615)[1]. |
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| Related Catalog | |
| In Vitro | MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1]. |
| References |
| Molecular Formula | C23H21FN6O3 |
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| Molecular Weight | 448.45 |
| InChIKey | WWNHSPXQGRANDX-UHFFFAOYSA-N |
| SMILES | Cc1nc(CCC(=O)O)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12 |
| Hazard Codes | Xi |
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