VCP/p97 inhibitor-1
Modify Date: 2025-08-25 11:50:57
VCP/p97 inhibitor-1 structure
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Common Name | VCP/p97 inhibitor-1 | ||
|---|---|---|---|---|
| CAS Number | 2630950-38-6 | Molecular Weight | 491.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H26BN5O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VCP/p97 inhibitor-1VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2]. |
| Name | VCP/p97 inhibitor-1 |
|---|
| Description | VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2]. |
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| Related Catalog | |
| Target |
54.7 nM (VCP/p97)[1] |
| In Vitro | VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1]. Cell Viability Assay[1] Cell Line: A549, RPMI8226 cells Concentration: 3-fold serial dilutions with the highest concentration at 10 μM Incubation Time: 72 hours Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC50= 2.9 and 0.86 μM, respectively). |
| References |
| Molecular Formula | C24H26BN5O4S |
|---|---|
| Molecular Weight | 491.37 |
| InChIKey | FOBHQTSQEGGBNP-UHFFFAOYSA-N |
| SMILES | Cc1cc2c(NS(C)(=O)=O)cccc2n1-c1nc2c(c(NCc3cccc(B(O)O)c3)n1)CCC2 |