Multitarget AD inhibitor-1
Modify Date: 2024-01-09 17:24:05
Multitarget AD inhibitor-1 structure
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Common Name | Multitarget AD inhibitor-1 | ||
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| CAS Number | 2205015-77-4 | Molecular Weight | 430.62 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H38N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Multitarget AD inhibitor-1Multitarget AD inhibitor-1 is a selective and reversible butyrylcholinesterase (BuChE) inhibitor with IC50s of 7.22 μM and 1.55 μM for hBuChE and eqBuChE, respectively. Multitarget AD inhibitor-1 inhibits β-secretase (IC50hBACE-1=41.60 μM), amyloid β aggregation (IC50 Aβ=3.09 μM), tau aggregation (55% at 10 μM). Multitarget AD inhibitor-1, a diphenylpropylamine derivative, has the potential for multifunctional disease-modifying anti-Alzheimer’s[1]. |
| Name | Multitarget AD inhibitor-1 |
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| Description | Multitarget AD inhibitor-1 is a selective and reversible butyrylcholinesterase (BuChE) inhibitor with IC50s of 7.22 μM and 1.55 μM for hBuChE and eqBuChE, respectively. Multitarget AD inhibitor-1 inhibits β-secretase (IC50hBACE-1=41.60 μM), amyloid β aggregation (IC50 Aβ=3.09 μM), tau aggregation (55% at 10 μM). Multitarget AD inhibitor-1, a diphenylpropylamine derivative, has the potential for multifunctional disease-modifying anti-Alzheimer’s[1]. |
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| Related Catalog | |
| In Vitro | Multitarget AD inhibitor-1 (compound 10) selectively inhibits BuChE from equine serum (eqBuChE) and hBuChE over AChE from electric eel (eeAChE; 21.78% at 10 μM)[1]. Multitarget AD inhibitor-1 (10 μM) inhibits full-length tau aggregation with 44.4%[1]. |
| References |
| Molecular Formula | C29H38N2O |
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| Molecular Weight | 430.62 |