1160501-81-4

1160501-81-4 structure

Name: PKC-theta inhibitor 1
Chemical Name: PKC-theta inhibitor 1
CAS Number: 1160501-81-4
Molecular Formula: C₁₇H₁₅F₃N₄O
Molecular Weight: 348.32
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2019-10-07 20:57:05
Modify Date: 2024-01-09 14:15:17
PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis[1].

Name	PKC-theta inhibitor 1

Description	PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Inflammation/Immunology Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCθ:6 nM (Ki) PKCδ:392 μM (Ki) PKCα:1020 μM (Ki) IL-2 production:0.19 μM (IC50)
References	[1]. Collier PN, et al. Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis. ACS Med Chem Lett. 2019 Jun 27;10(8):1134-1139.

Molecular Formula	C₁₇H₁₅F₃N₄O
Molecular Weight	348.32