2630950-38-6

2630950-38-6 structure

Name: VCP/p97 inhibitor-1
Chemical Name: VCP/p97 inhibitor-1
CAS Number: 2630950-38-6
Molecular Formula: C₂₄H₂₆BN₅O₄S
Molecular Weight: 491.37
Catalog: Signaling Pathways Cell Cycle/DNA Damage p97
Create Date: 2022-02-22 19:09:56
Modify Date: 2025-08-25 11:50:57
VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].

Name	VCP/p97 inhibitor-1

Description	VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> p97
Target	54.7 nM (VCP/p97)[1]
In Vitro	VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1]. Cell Viability Assay[1] Cell Line: A549, RPMI8226 cells Concentration: 3-fold serial dilutions with the highest concentration at 10 μM Incubation Time: 72 hours Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC50= 2.9 and 0.86 μM, respectively).
References	[1]. Zhang Y, et al. Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors. Bioorg Med Chem. 2021;38:116114. [2]. van den Boom J, et al. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69(2):182-194.

Molecular Formula	C₂₄H₂₆BN₅O₄S
Molecular Weight	491.37