4-Hydroxymethylpyrazole

Modify Date: 2024-01-09 17:26:51

4-Hydroxymethylpyrazole Structure
4-Hydroxymethylpyrazole structure
Common Name 4-Hydroxymethylpyrazole
CAS Number 25222-43-9 Molecular Weight 98.103
Density 1.3±0.1 g/cm3 Boiling Point 326.8±17.0 °C at 760 mmHg
Molecular Formula C4H6N2O Melting Point N/A
MSDS N/A Flash Point 151.5±20.9 °C

 Use of 4-Hydroxymethylpyrazole


4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase[1].

 Names

Name 1H-pyrazol-4-ylmethanol
Synonym More Synonyms

 4-Hydroxymethylpyrazole Biological Activity

Description 4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase[1].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. R Blomstrand, et al. Pyrazoles as Inhibitors of Alcohol Oxidation and as Important Tools in Alcohol Research: An Approach to Therapy Against Methanol Poisoning. Proc Natl Acad Sci U S A . 1979 Jul;76(7):3499-503.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 326.8±17.0 °C at 760 mmHg
Molecular Formula C4H6N2O
Molecular Weight 98.103
Flash Point 151.5±20.9 °C
Exact Mass 98.048012
PSA 48.91000
LogP -0.87
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.590

 Safety Information

Hazard Codes Xi
HS Code 2933199090

 Synthetic Route

~75%

4-Hydroxymethylpyrazole Structure

4-Hydroxymethyl...

CAS#:25222-43-9

Literature: Bur, Daniel; Gude, Markus; Hubschwerlen, Christian; Panchaud, Philippe Patent: US2013/96119 A1, 2013 ; Location in patent: Paragraph 1626; 1627 ;

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4-Hydroxymethylpyrazole Structure

4-Hydroxymethyl...

CAS#:25222-43-9

Literature: Journal of the American Chemical Society, , vol. 71, p. 4000

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4-Hydroxymethylpyrazole Structure

4-Hydroxymethyl...

CAS#:25222-43-9

Detail
Literature: Journal of the American Chemical Society, , vol. 71, p. 4000

 Customs

HS Code 2933199090
Summary 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1H-Pyrazole-4-methanol
1H-Pyrazol-4-ylmethanol
pyrazol-4-ylmethan-1-ol
4-Hydroxymethyl-pyrazol