4-Hydroxymethylpyrazole

Names

[ Name ]:
4-Hydroxymethylpyrazole

[Synonym ]:
1H-Pyrazole-4-methanol
1H-Pyrazol-4-ylmethanol
pyrazol-4-ylmethan-1-ol
4-Hydroxymethyl-pyrazol

Biological Activity

[Description]:

4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876). Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase[1].

[Related Catalog]:

Research Areas >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. R Blomstrand, et al. Pyrazoles as Inhibitors of Alcohol Oxidation and as Important Tools in Alcohol Research: An Approach to Therapy Against Methanol Poisoning. Proc Natl Acad Sci U S A . 1979 Jul;76(7):3499-503.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
326.8±17.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₆N₂O

[ Molecular Weight ]:
98.103

[ Flash Point ]:
151.5±20.9 °C

[ Exact Mass ]:
98.048012

[ PSA ]:
48.91000

[ LogP ]:
-0.87

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.590

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933199090

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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