PAK1-IN-1
Modify Date: 2025-08-26 16:24:04
PAK1-IN-1 structure
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Common Name | PAK1-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2485732-30-5 | Molecular Weight | 469.92 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H20ClN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PAK1-IN-1PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1]. |
| Name | PAK1-IN-1 |
|---|
| Description | PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1]. |
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| Related Catalog | |
| Target |
PAK1:9.8 nM (IC50) PAK4:>10 μM (IC50) |
| In Vitro | PAK1-IN-1 (compound 30l) (0-10 µM) shows selectivity with IC50s of 0.01, >10 µM for PAK1 and PAK4, respectively[1]. Cell Proliferation Assay[1] Cell Line: MDA-MB-231, HCT-116 cells Concentration: 1 µM Incubation Time: 72 h Result: Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively. Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 2.5, 5, 10, 20 µM Incubation Time: 1, 24 h Result: Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner. |
| References |
| Molecular Formula | C26H20ClN5O2 |
|---|---|
| Molecular Weight | 469.92 |