IDH2R140Q-IN-1

Modify Date: 2025-08-27 13:57:27

IDH2R140Q-IN-1 structure	Common Name	IDH2R140Q-IN-1
	CAS Number	2469044-23-1	Molecular Weight	482.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₀F₆N₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IDH2R140Q-IN-1

IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2R140Q, with an IC50 of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia[1].

Name	IDH2R140Q-IN-1

Description	IDH2R140Q-IN-1 (compound C6) is a potent inhibitor of IDH2R140Q, with an IC50 of 6.1 nM. IDH2R140Q-IN-1 can be used for the research of acute myeloid leukemia[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)
References	[1]. Che J, et, al. Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells. Eur J Med Chem. 2020 Oct 1;203:112491.

Molecular Formula	C₂₂H₂₀F₆N₆
Molecular Weight	482.42
InChIKey	UTJJIEVWKZKWEI-UHFFFAOYSA-N
SMILES	FC(F)(F)c1cc2cc(c1)Nc1nc(nc(-c3cccc(C(F)(F)F)n3)n1)NCCCCCC2

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