IDH2R140Q-IN-1

• 常用名: IDH2R140Q-IN-1
• 英文名: IDH2R140Q-IN-1
• CAS号: 2469044-23-1
• 分子量: 482.42
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₀F₆N₆
• 熔点: N/A
• 闪点: N/A

IDH2R140Q-IN-1用途

IDH2R140Q-IN-1(化合物C6)是IDH2R140Q的有效抑制剂,IC50为6.1 nM。IDH2R140Q-IN-1可用于急性髓系白血病的研究[1]。

IDH2R140Q-IN-1名称

• 英文名: IDH2R140Q-IN-1

IDH2R140Q-IN-1生物活性

• 描述: IDH2R140Q-IN-1(化合物C6)是IDH2R140Q的有效抑制剂,IC50为6.1 nM。IDH2R140Q-IN-1可用于急性髓系白血病的研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 异柠檬酸脱氢酶(IDH)
• 参考文献:

  [1]. Che J, et, al. Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells. Eur J Med Chem. 2020 Oct 1;203:112491.

IDH2R140Q-IN-1物理化学性质

• 分子式: C₂₂H₂₀F₆N₆
• 分子量: 482.42
• InChIKey: UTJJIEVWKZKWEI-UHFFFAOYSA-N
• SMILES: FC(F)(F)c1cc2cc(c1)Nc1nc(nc(-c3cccc(C(F)(F)F)n3)n1)NCCCCCC2