HDAC3/6-IN-2

Modify Date: 2024-01-10 12:56:41

HDAC3/6-IN-2 structure	Common Name	HDAC3/6-IN-2
	CAS Number	2417510-17-7	Molecular Weight	822.09
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₉H₆₇N₅O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDAC3/6-IN-2

HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].

Name	HDAC3/6-IN-2

Description	HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:0.368 μM (IC50) HDAC3:0.635 μM (IC50) HDAC1:2.512 μM (IC50) HDAC2:4.830 μM (IC50)
References	[1]. Huang M, Xie X, Gong P, et al. A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects. Eur J Med Chem. 2020;188:111991.

Molecular Formula	C₄₉H₆₇N₅O₆
Molecular Weight	822.09

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

HDAC3/6-IN-2

Use of HDAC3/6-IN-2

Names

HDAC3/6-IN-2 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.