HDAC3/6-IN-2

Names

[ CAS No. ]:
2417510-17-7

[ Name ]:
HDAC3/6-IN-2

Biological Activity

[Description]:

HDAC3/6-IN-2 (compound 15) is a potent HDAC6 and HDAC3 inhibitor, with IC50 values of 0.368 and 0.635 μM, respectively. HDAC3/6-IN-2 shows antitumor activity, and induces cancer cell apoptosis. HDAC3/6-IN-2 decreases the levels of HDAC6 and HDAC3, associated with upregulation of acetylated H3 and α-tubulin[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC6:0.368 μM (IC50)

HDAC3:0.635 μM (IC50)

HDAC1:2.512 μM (IC50)

HDAC2:4.830 μM (IC50)


[References]

[1]. Huang M, Xie X, Gong P, et al. A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects. Eur J Med Chem. 2020;188:111991.

Chemical & Physical Properties

[ Molecular Formula ]:
C49H67N5O6

[ Molecular Weight ]:
822.09

Related Compounds

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