ThrRS-IN-1

Modify Date: 2024-01-16 16:39:07

ThrRS-IN-1 structure	Common Name	ThrRS-IN-1
	CAS Number	2408626-64-0	Molecular Weight	385.25
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₈Cl₂N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ThrRS-IN-1

ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1].

Name	ThrRS-IN-1

Description	ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 1.4 µM (SeThrRS)[1]
References	[1]. Junsong Guo, et al. Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping. Eur J Med Chem. 2020 Feb 1;187:111941.

Molecular Formula	C₁₆H₁₈Cl₂N₄O₃
Molecular Weight	385.25

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ThrRS-IN-1

Use of ThrRS-IN-1

Names

ThrRS-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.