2408626-64-0

2408626-64-0 structure

Name: ThrRS-IN-1
Chemical Name: ThrRS-IN-1
CAS Number: 2408626-64-0
Molecular Formula: C₁₆H₁₈Cl₂N₄O₃
Molecular Weight: 385.25
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-08-14 17:51:22
Modify Date: 2024-01-16 16:39:07
ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1].

Name	ThrRS-IN-1

Description	ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 1.4 µM (SeThrRS)[1]
References	[1]. Junsong Guo, et al. Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping. Eur J Med Chem. 2020 Feb 1;187:111941.

Molecular Formula	C₁₆H₁₈Cl₂N₄O₃
Molecular Weight	385.25