ThrRS-IN-1

Names

[ Name ]:
ThrRS-IN-1

Biological Activity

[Description]:

ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 1.4 µM (SeThrRS)[1]

[References]

[1]. Junsong Guo, et al. Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping. Eur J Med Chem. 2020 Feb 1;187:111941.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₈Cl₂N₄O₃

[ Molecular Weight ]:
385.25

Related Compounds

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