QX 314 bromide
Modify Date: 2025-08-26 18:01:05
QX 314 bromide structure
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Common Name | QX 314 bromide | ||
|---|---|---|---|---|
| CAS Number | 24003-58-5 | Molecular Weight | 343.30200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H27BrN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of QX 314 bromideQX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1]. |
| Name | QX-314 (bromide) |
|---|---|
| Synonym | More Synonyms |
| Description | QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1]. |
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| Related Catalog | |
| Target |
sodium channel[1] |
| In Vitro | QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro [1]. QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[1]. QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death [1]. QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 10% of control amplitude [3]. QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- [3]. |
| In Vivo | QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin[2]. Animal Model: Male Sprague-Dawley rats (250-290 g)[2] Dosage: 1.6 mg/kg Administration: Intracutaneous injection Result: Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin. |
| References |
| Molecular Formula | C16H27BrN2O |
|---|---|
| Molecular Weight | 343.30200 |
| Exact Mass | 342.13100 |
| PSA | 29.10000 |
| LogP | 0.19540 |
|
~%
QX 314 bromide CAS#:24003-58-5 |
| Literature: Loefgren; Fischer Svensk Kemisk Tidskrift, 1946 , vol. 58, p. 219,229 |
| Precursor 2 | |
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| DownStream 0 | |
| Hepato-Scan |
| Lidofenin |
| 2,6-dimethylacetanilideiminodiacetic acid |
| Ellipticine |
| Lidocaine N-ethyl bromide |
| Hida |