5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

Modify Date: 2024-01-02 14:12:35

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine structure	Common Name	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
	CAS Number	23669-79-6	Molecular Weight	530.56800
	Density	1.294 g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₀N₂O₇	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks[1][2].

Name	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Synonym	More Synonyms

Description	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	Ki: >1000 μM (E. coli dUTPase)[1]
References	[1]. Hidalgo-Zarco F, et, al. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major. Protein Sci. 2001 Jul;10(7):1426-33. [2]. Hovinen J, et, al. Versatile strategy for oligonucleotide derivatization. Introduction of lanthanide(III) chelates to oligonucleotides. Org Lett. 2001 Aug 9;3(16):2473-6.

Density	1.294 g/cm3
Molecular Formula	C₃₀H₃₀N₂O₇
Molecular Weight	530.56800
Exact Mass	530.20500
PSA	112.01000
LogP	3.21090
Appearance of Characters	Powder \| White to Off-white
Index of Refraction	1.61
Storage condition	−20°C
Water Solubility	Soluble in acetonitrile at 20mg/ml

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H332-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/22;R36/37/38
Safety Phrases	S22-S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3

2'-deoxyuridine

CAS#:951-78-0

4,4'-Dimethoxyt...

CAS#:40615-36-9

~10%

5'-O-(4,4'-Dime...

CAS#:23669-79-6

Literature: Avino, Anna; Garcia, Ramon Gueimil; Albericio, Fernando; Mann, Matthias; Wilm, Matthias; Neubauer, Gitte; Eritja, Ramon Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 10 p. 1649 - 1658