5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

Names

[ Name ]:
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

[Synonym ]:
5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxyuridine
5'-O-Dimethylterephthale-2'-deoxyuridine
5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine
5'-O-DMT-2'-DEOXYURIDINE
2'-deoxy-5'-O-dimethoxytrityluridine
DMT-DEOXYURIDINE
2'-deoxy-5'-(4,4'-dimethoxytrityl)uridine
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyuridine
dmt-du
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-uridine
5'-O-(4,4'-dimetoxytrityl)-2'-deoxyuridine
2'-Deoxy-5'-O-DMT-uridine

Biological Activity

[Description]:

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

Ki: >1000 μM (E. coli dUTPase)[1]

[References]

[1]. Hidalgo-Zarco F, et, al. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major. Protein Sci. 2001 Jul;10(7):1426-33.

[2]. Hovinen J, et, al. Versatile strategy for oligonucleotide derivatization. Introduction of lanthanide(III) chelates to oligonucleotides. Org Lett. 2001 Aug 9;3(16):2473-6.

Chemical & Physical Properties

[ Density]:
1.294 g/cm3

[ Molecular Formula ]:
C₃₀H₃₀N₂O₇

[ Molecular Weight ]:
530.56800

[ Exact Mass ]:
530.20500

[ PSA ]:
112.01000

[ LogP ]:
3.21090

[ Appearance of Characters ]:
Powder | White to Off-white

[ Index of Refraction ]:
1.61

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in acetonitrile at 20mg/ml

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/22;R36/37/38

[ Safety Phrases ]:
S22-S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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