Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

23669-79-6

23669-79-6 structure

Name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Chemical Name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
CAS Number: 23669-79-6
Molecular Formula: C₃₀H₃₀N₂O₇
Molecular Weight: 530.56800
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-07-21 18:51:13
Modify Date: 2024-01-02 14:12:35
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks[1][2].

Name	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Synonyms	5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxyuridine 5'-O-Dimethylterephthale-2'-deoxyuridine 5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine 5'-O-DMT-2'-DEOXYURIDINE 2'-deoxy-5'-O-dimethoxytrityluridine DMT-DEOXYURIDINE 2'-deoxy-5'-(4,4'-dimethoxytrityl)uridine 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyuridine dmt-du 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-uridine 5'-O-(4,4'-dimetoxytrityl)-2'-deoxyuridine 2'-Deoxy-5'-O-DMT-uridine

Description	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) is a competitive inhibitor of E. coli dUTP nucleotidohydrolase (dUTPase), with the Ki higher than 1000 μM. 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine can be used in machine-assisted DNA synthesis by synthesizing nucleosidic phosphoramidite blocks[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	Ki: >1000 μM (E. coli dUTPase)[1]
References	[1]. Hidalgo-Zarco F, et, al. Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major. Protein Sci. 2001 Jul;10(7):1426-33. [2]. Hovinen J, et, al. Versatile strategy for oligonucleotide derivatization. Introduction of lanthanide(III) chelates to oligonucleotides. Org Lett. 2001 Aug 9;3(16):2473-6.

Density	1.294 g/cm3
Molecular Formula	C₃₀H₃₀N₂O₇
Molecular Weight	530.56800
Exact Mass	530.20500
PSA	112.01000
LogP	3.21090
Appearance	Powder \| White to Off-white
Index of Refraction	1.61
Storage condition	−20°C
Water Solubility	Soluble in acetonitrile at 20mg/ml

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H332-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/22;R36/37/38
Safety Phrases	S22-S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3

951-78-0

40615-36-9

~10%

23669-79-6

Literature: Avino, Anna; Garcia, Ramon Gueimil; Albericio, Fernando; Mann, Matthias; Wilm, Matthias; Neubauer, Gitte; Eritja, Ramon Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 10 p. 1649 - 1658

1254223-76-1

23669-79-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 4 p. 1181 - 1184

40615-36-9

23669-79-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 4 p. 1181 - 1184

40615-35-8

23669-79-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 4 p. 1181 - 1184

Precursor 3
951-78-0 40615-36-9 40615-35-8
DownStream 1
76512-82-8

23669-79-6	177980-10-8
117626-97-8	118849-17-5
500907-27-7	1000852-26-5
17331-22-5	76512-82-8
830322-55-9	302918-83-8