CP-544439
Modify Date: 2024-01-02 09:35:54
CP-544439 structure
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Common Name | CP-544439 | ||
|---|---|---|---|---|
| CAS Number | 230954-09-3 | Molecular Weight | 410.41700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H19FN2O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CP-544439CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2]. |
| Name | 4-[4-(4-fluoro-phenoxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide |
|---|---|
| Synonym | More Synonyms |
| Description | CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2]. |
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| Related Catalog | |
| Target |
MMP-13:0.75 nM (IC50) MMP-12:0.24 nM (IC50) MMP-1:420 nM (IC50) MMP-2:1.6 nM (IC50) MMP-3:16 nM (IC50) MMP-8:1.4 nM (IC50) MMP-9:12 nM (IC50) MMP-14:7.4 nM (IC50) |
| In Vivo | In vivo studies using a hamster model, in which the cartilage collagen degradation was induced by intra-articular injection of recombinant human MMP-13, demonstrated that oral administration of CP-544439 inhibits degradation of the cartilage collagen with an ED50 of 14 mg/kg and efficacious plasma concentrations ranging from 0.5 to 1.0 g/ml[1]. |
| References |
| Molecular Formula | C18H19FN2O6S |
|---|---|
| Molecular Weight | 410.41700 |
| Exact Mass | 410.09500 |
| PSA | 122.34000 |
| LogP | 3.81350 |
| 4-[4-(4-fluoro-phenoxy)-benzenesulfonylamino]-tetrahydro-pyran4-carboxylic acid hydroxyamide |
| 4-[4-(4-fluorophenoxy)benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide |
| 4-[4-(4-fluorophenoxy)benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid hydroxyamide |
| 4-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide |
| 4-[4-(4-fluoro-phenoxy)-benzenesulfonylamino]tetrahydro-pyran-4-carboxylic acid hydroxyamide |