hGGPPS-IN-2

Modify Date: 2025-08-27 17:22:01

hGGPPS-IN-2 Structure
hGGPPS-IN-2 structure
Common Name hGGPPS-IN-2
CAS Number 2241547-82-8 Molecular Weight 553.40
Density N/A Boiling Point N/A
Molecular Formula C20H18FN5O7P2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of hGGPPS-IN-2


hGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].

 Names

Name hGGPPS-IN-2

 hGGPPS-IN-2 Biological Activity

Description hGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
Related Catalog
References

[1]. Lee HF, et al. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem. 2022;65(3):2471-2496.

 Chemical & Physical Properties

Molecular Formula C20H18FN5O7P2S
Molecular Weight 553.40
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