2241547-82-8

2241547-82-8 structure

Name: hGGPPS-IN-2
Chemical Name: hGGPPS-IN-2
CAS Number: 2241547-82-8
Molecular Formula: C₂₀H₁₈FN₅O₇P₂S
Molecular Weight: 553.40
Create Date: 2022-05-17 10:53:37
Modify Date: 2025-08-27 17:22:01
hGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].

Name	hGGPPS-IN-2

Description	hGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Lee HF, et al. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem. 2022;65(3):2471-2496.

Molecular Formula	C₂₀H₁₈FN₅O₇P₂S
Molecular Weight	553.40