NAMPT inhibitor-linker 1
Modify Date: 2025-08-27 00:28:51
NAMPT inhibitor-linker 1 structure
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Common Name | NAMPT inhibitor-linker 1 | ||
|---|---|---|---|---|
| CAS Number | 2241019-57-6 | Molecular Weight | 668.71 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C36H37FN6O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NAMPT inhibitor-linker 1NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively. |
| Name | NAMPT inhibitor-linker 1 |
|---|
| Description | NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively. |
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| Related Catalog | |
| In Vitro | ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <3 pM and 9 pM, respectively[1]. |
| In Vivo | ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells[1]. Animal Model: Female scid-beige (SCID bg) mice[1] Dosage: 20 mg/kg Administration: A single intravenous injection (i.v.) for 28 days Result: Significantly inhibited the growth of tumor in mice. |
| References |
| Molecular Formula | C36H37FN6O6 |
|---|---|
| Molecular Weight | 668.71 |
| InChIKey | ZIJGVXBDFVHKQP-IHLOFXLRSA-N |
| SMILES | O=C(NCc1ccc(NC(=O)C2CC2c2cccnc2)cc1F)c1ccc(N2CCN(C(=O)CCOCCN3C(=O)C=CC3=O)CC2)cc1 |