Flutamide-d7

Modify Date: 2024-01-28 10:01:44

Flutamide-d7 structure	Common Name	Flutamide-d7
	CAS Number	223134-72-3	Molecular Weight	283.25
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₄D₇F₃N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Flutamide-d7

Flutamide-d7 is deuterium labeled Flutamide.

Name	Flutamide-d7

Description	Flutamide-d7 is deuterium labeled Flutamide.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44(3):261-70. [3]. Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31(5):845-52. [4]. Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321(7):419-24. [5]. Marchetti B, et al. Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochem. 1988 Jun;29(6):691-8.

Molecular Formula	C₁₁H₄D₇F₃N₂O₃
Molecular Weight	283.25