Flutamide-d7

• 常用名: Flutamide-d7
• 英文名: Flutamide-d7
• CAS号: 223134-72-3
• 分子量: 283.25
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₄D₇F₃N₂O₃
• 熔点: N/A
• 闪点: N/A

Flutamide-d7用途

氟他胺-d7是氘标记的氟他胺。

Flutamide-d7名称

• 英文名: Flutamide-d7

Flutamide-d7生物活性

• 描述: 氟他胺-d7是氘标记的氟他胺。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 雄激素受体
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44(3):261-70.

  [3]. Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31(5):845-52.

  [4]. Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321(7):419-24.

  [5]. Marchetti B, et al. Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochem. 1988 Jun;29(6):691-8.

Flutamide-d7物理化学性质

• 分子式: C₁₁H₄D₇F₃N₂O₃
• 分子量: 283.25
• InChIKey: MKXKFYHWDHIYRV-NWOXSKRJSA-N
• SMILES: CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1