GSK-3 inhibitor 4

Modify Date: 2024-01-26 14:36:05

GSK-3 inhibitor 4 structure	Common Name	GSK-3 inhibitor 4
	CAS Number	2227279-83-4	Molecular Weight	403.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₅F₂N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GSK-3 inhibitor 4

GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies[1].

Name	GSK-3 inhibitor 4

Description	GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3α:0.45 nM (IC50) GSK-3β:0.56 nM (IC50) CDK2:0.47 μM (IC50) CDK5:0.68 μM (IC50)
References	[1]. Hartz RA, et al. Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. J Med Chem. 2023 Jun 8;66(11):7534-7552.

Molecular Formula	C₂₂H₁₅F₂N₅O
Molecular Weight	403.38

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GSK-3 inhibitor 4
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Purity: 98.77%
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