2227279-83-4

2227279-83-4 structure

Name: GSK-3 inhibitor 4
Chemical Name: GSK-3 inhibitor 4
CAS Number: 2227279-83-4
Molecular Formula: C₂₂H₁₅F₂N₅O
Molecular Weight: 403.38
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2023-09-19 05:42:45
Modify Date: 2024-01-26 14:36:05
GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies[1].

Name	GSK-3 inhibitor 4

Description	GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM, and 0.68 μM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimer's disease (AD) studies[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3α:0.45 nM (IC50) GSK-3β:0.56 nM (IC50) CDK2:0.47 μM (IC50) CDK5:0.68 μM (IC50)
References	[1]. Hartz RA, et al. Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. J Med Chem. 2023 Jun 8;66(11):7534-7552.

Molecular Formula	C₂₂H₁₅F₂N₅O
Molecular Weight	403.38