BMS-986313
Modify Date: 2025-08-25 18:28:44
BMS-986313 structure
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Common Name | BMS-986313 | ||
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| CAS Number | 2226319-10-2 | Molecular Weight | 599.536 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H25F8NO4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMS-986313BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.BMS-986313 demonstrated robust efficacy in preclinical models of psoriasis (the IMQ-induced skin lesion model and the IL-23-induced acanthosis model). |
| Name | BMS-986313 |
|---|
| Description | BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.BMS-986313 demonstrated robust efficacy in preclinical models of psoriasis (the IMQ-induced skin lesion model and the IL-23-induced acanthosis model). |
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| References | 1. Yang MG, et al. J Med Chem. 2021 Mar 11;64(5):2714-2724. |
| Molecular Formula | C26H25F8NO4S |
|---|---|
| Molecular Weight | 599.536 |