2226319-10-2
2226319-10-2 structure
- Name: BMS-986313
- Chemical Name: BMS-986313
- CAS Number: 2226319-10-2
- Molecular Formula: C26H25F8NO4S
- Molecular Weight: 599.536
- Create Date: 2022-07-11 11:29:47
- Modify Date: 2025-08-25 18:28:44
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BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.BMS-986313 demonstrated robust efficacy in preclinical models of psoriasis (the IMQ-induced skin lesion model and the IL-23-induced acanthosis model).
| Name | BMS-986313 |
|---|
| Description | BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.BMS-986313 demonstrated robust efficacy in preclinical models of psoriasis (the IMQ-induced skin lesion model and the IL-23-induced acanthosis model). |
|---|---|
| References | 1. Yang MG, et al. J Med Chem. 2021 Mar 11;64(5):2714-2724. |
| Molecular Formula | C26H25F8NO4S |
|---|---|
| Molecular Weight | 599.536 |