Sotuletinib dihydrochloride

Modify Date: 2025-08-25 11:21:49

Sotuletinib dihydrochloride structure	Common Name	Sotuletinib dihydrochloride
	CAS Number	2222138-40-9	Molecular Weight	471.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₄Cl₂N₄O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Sotuletinib dihydrochloride

Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC50=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research[1].

Name	Sotuletinib dihydrochloride

Description	Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC50=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms Research Areas >> Neurological Disease
Target	IC50: CSF1-R (1 nM)[1].
References	[1]. Pyonteck SM, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013 Oct;19(10):1264-72. [2]. Pognan F, et al. Liver enzyme delayed clearance in rat treated by CSF1 receptor specific antagonist Sotuletinib. Curr Res Toxicol. 2022 Oct 29;3:100091.

Molecular Formula	C₂₀H₂₄Cl₂N₄O₃S
Molecular Weight	471.40
InChIKey	ZIHWHYXECXSBNA-LVVRIOTCSA-N
SMILES	CNC(=O)c1cc(Oc2ccc3nc(NC4CCCCC4O)sc3c2)ccn1.Cl.Cl

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Sotuletinib dihydrochloride
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Sotuletinib dihydrochloride
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

Sotuletinib dihydrochloride suppliers

Sotuletinib dihydrochloride price

Sotuletinib dihydrochloride

Use of Sotuletinib dihydrochloride

Names

Sotuletinib dihydrochloride Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.