Sotuletinib dihydrochloride

Names

[ Name ]:
Sotuletinib dihydrochloride

Biological Activity

[Description]:

Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC50=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms

Research Areas >> Neurological Disease

[Target]

IC50: CSF1-R (1 nM)[1].

[References]

[1]. Pyonteck SM, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013 Oct;19(10):1264-72.

[2]. Pognan F, et al. Liver enzyme delayed clearance in rat treated by CSF1 receptor specific antagonist Sotuletinib. Curr Res Toxicol. 2022 Oct 29;3:100091.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄Cl₂N₄O₃S

[ Molecular Weight ]:
471.40

Related Compounds

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