2222138-40-9

2222138-40-9 structure

Name: Sotuletinib dihydrochloride
Chemical Name: Sotuletinib dihydrochloride
CAS Number: 2222138-40-9
Molecular Formula: C₂₀H₂₄Cl₂N₄O₃S
Molecular Weight: 471.40
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
Create Date: 2023-09-19 18:12:03
Modify Date: 2024-01-04 12:26:22
Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC50=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research[1].

Name	Sotuletinib dihydrochloride

Description	Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC50=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms Research Areas >> Neurological Disease
Target	IC50: CSF1-R (1 nM)[1].
References	[1]. Pyonteck SM, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013 Oct;19(10):1264-72. [2]. Pognan F, et al. Liver enzyme delayed clearance in rat treated by CSF1 receptor specific antagonist Sotuletinib. Curr Res Toxicol. 2022 Oct 29;3:100091.

Molecular Formula	C₂₀H₂₄Cl₂N₄O₃S
Molecular Weight	471.40