L-Canavanine sulfate

Modify Date: 2025-08-21 21:19:12

L-Canavanine sulfate Structure
L-Canavanine sulfate structure
 Common Name L-Canavanine sulfate
CAS Number 2219-31-0 Molecular Weight 274.252
Density N/A Boiling Point 574ºC at 760mmHg
Molecular Formula C5H14N4O7S Melting Point 160-165 °C (dec.)
MSDS Chinese USA Flash Point 300.9ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of L-Canavanine sulfate


L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.

 Names

Name L-canavanine sulfate
Synonym More Synonyms

 L-Canavanine sulfate Biological Activity

Description L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
Related Catalog
Target

NO synthase[1]

In Vitro L-Canavanine sulfate (L-CAV) causes only a limited degree of cytotoxicity in HeLa, Hep G2, and SK-HEP-1 cells when given alone in arginine-rich media with IC50 values ranging from 5 to 10 mM. In HaCaT keratinocyte cell line, IC50 of L-Canavanine sulfate exceeds the concentration of 10 mM, indicating low cytotoxicity in normal cells in vitro. In arginine-free media, IC50 of L-Canavanine sulfate in HeLa, Hep G2, and SK-HEP-1 cells are 0.21±0.04; 0.64±0.16; and 1.18±0.14 mM, respectively. L-Canavanine sulfate, which is hardly toxic alone, potentiates the cytotoxicity of vinblastine (VIN) and paclitaxel (PTX) in HeLa and hepatocellular carcinoma cells[2].
In Vivo Administration of L-Canavanine sulfate (100 mg/kg) produces a moderate increase in mean arterial pressure of 20 mm Hg, returns blood pressure to near basal levels and completely attenuates the lipopolysaccharide-induced hypotension. All, but one, endotoxaemic rats dosed with L-Canavanine sulfate (100 mg/kg) survive for 6 h post lipopolysaccharide, after which time the experiment is terminated (n=7)[1]. L-canavanine inhibits DNA synthesis by Li 210 cells in vivo and significantly increases the lifespan of animals bearing the Li 210 leukemia. An optimal dose of 18 g/kg produces a peak increase in lifespan of 44%. The therapeutic dose range is narrow, and a dose of 24 g/kg causes death due to drug toxicity[3].
Cell Assay A dose-dependent cytotoxicity is examined using the MTT assay. Into each well of 96-well plates, 2×104 of cells are seeded, and after 24 h incubation, cells are incubated with test compounds (including L-Canavanine sulfate). After 24 h, 0.5 mg/mL of MTT is added to each well of HeLa, Caco-2, MIA PaCa-2, BxPC-3 and SK-HEP-1 cells, while MTT is added to Hep G2 after 48 h incubation with test compounds (including L-Canavanine sulfate). The cells are then incubated for 3 h so that the viable cells could produce formazan crystals; they are then dissolved in 100 μL DMSO. After incubation for 10 min in a shaker, the absorption of the formazan is measured at 570 nm using a reader[2].
Animal Admin Male rats weighing 295 to 305 g are used. After a period of stabilization, 6 mg lipopolysaccharide/kg is administered intravenously in 0.3 mL over 2 min, and cardiovascular parameters are monitored over 5 to 6 h. L-Canavanine sulfate is administered intravenously in a 0.2 mL volume bolus injection at 100 mg/kg[1]. Mice: L-Canavanine is dissolved in phosphate-buffered saline[1]. L-Canavanine (100 mg/mb) is infused at a rate of 0.1 mL/hr through a catheter implanted S.C. over the back. Groups of 5 mice are treated at each dose beveltogether with 6 to 8 control animals and are inspected twice per day for median time of death[1].
References

[1]. Teale DM, et al. L-canavanine restores blood pressure in a rat model of endotoxic shock. Eur J Pharmacol. 1994 Dec 12;271(1):87-92.

[2]. Nurcahyanti AD, et al. Cytotoxic potentiation of vinblastine and paclitaxel by L-canavanine in human cervical cancer and hepatocellular carcinoma cells. Phytomedicine. 2015 Dec 15;22(14):1232-7.

[3]. Green MH, et al. Antitumor activity of L-canavanine against L1210 murine leukemia. Cancer Res. 1980 Mar;40(3):535-7.

 Chemical & Physical Properties

Boiling Point 574ºC at 760mmHg
Melting Point 160-165 °C (dec.)
Molecular Formula C5H14N4O7S
Molecular Weight 274.252
Flash Point 300.9ºC
Exact Mass 274.058319
PSA 217.43000
LogP 0.52230
Appearance of Characters powder | white
Vapour Pressure 1.21E-08mmHg at 25°C
Storage condition 2-8°C
Water Solubility H2O: 100 mg/mL

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S36
RIDADR 2811
WGK Germany 3
HS Code 2925290090

 Customs

HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles4

More Articles
Determination of L-canavanine and other free amino acids in Vicia disperma (Fabaceae) seeds by precolumn derivatization using diethyl ethoxymethylenemalonate and reversed-phase high-performance liquid chromatography.

Talanta 131 , 95-8, (2014)

A method for determination of the non-protein amino acid l-α-amino-γ-(guanidinooxy)-n-butyric acid (L-canavanine) and other free amino acids in Vicia disperma is presented. Seed extracts were derivati...

Quality control of a transcriptional regulator by SUMO-targeted degradation.

Mol. Cell. Endocrinol. 29 , 1694-706, (2009)

Slx5 and Slx8 are heterodimeric RING domain-containing proteins that possess SUMO-targeted ubiquitin ligase (STUbL) activity in vitro. Slx5-Slx8 and its orthologs are proposed to target SUMO conjugate...

Dissection of genetically complex traits with extremely large pools of yeast segregants.

Nanotechnology 464 , 1039-42, (2010)

Most heritable traits, including many human diseases, are caused by multiple loci. Studies in both humans and model organisms, such as yeast, have failed to detect a large fraction of the loci that un...

 Synonyms

CANAVANINE SULFATE,L
L-Canavanine sulphate
L-Canavanine Sulfate Hydrate
L-CANAVANINE SULFATE
O-Guanidino-L-homoserin,Sulfat
L-Homoserine, O-[(diaminomethylene)amino]-, sulfate (1:1)
O-[(Diaminomethylene)amino]-L-homoserine sulfate (1:1)
Canavanine sulfate
EINECS 218-728-4
O-guanidino-L-homoserine,sulfate
L-Canavanine sulfate salt
L-HOMOSERINE, O-((AMINOIMINOMETHYL)AMINO)-, SULFATE (1:1)
MFCD00012618
canavanine sulphate
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

L-Canavanine sulfate suppliers

Price: $66/10mM*1mLinWater

Reference only. check more L-Canavanine sulfate price

Related Compounds: More...
DL-Canavanine sulfate
34221-38-0
DL-Canavanine sulfate
1078611-11-6
l-(+)-canavanine sulfate monohydrate 9&
206996-57-8
(L)-Canavanine
543-38-4
Ephedrine sulfate
134-72-5
L-KYNURENINE SULFATE
13535-93-8
l-Isoproterenol sulfate
13764-54-0
L-Ornithine sulfate
6153-43-1
L -Kynurenine sulfate salt
16055-80-4
1-[3-(2-Methylphenyl)phenyl]cyclopropan-1-amine
2228315-88-4
(3R)-5-amino-1-phenylpent-1-en-3-ol
2227913-87-1
4-[(Prop-2-en-1-yloxy)methyl]-1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid
2680863-13-0
9-(2,2,2-Trifluoroacetyl)-3-oxa-9-azaspiro[5.5]undecane-7-carboxylic acid
2680720-02-7
2-(2,2,2-Trifluoroacetamido)furo[3,2-b]pyridine-3-carboxylic acid
2680895-58-1
2-(2,2,2-Trifluoroacetamido)-5-(trifluoromethyl)-1,3-thiazole-4-carboxylic acid
2680707-18-8
1-{[4-(2,2,2-trifluoroacetyl)morpholin-2-yl]methyl}-1H-1,2,3-triazole-4-carboxylic acid
2680877-43-2
3-(3-Methoxy-1,2-oxazol-5-yl)butan-1-amine
1512412-54-2
N-(4-ethynylphenyl)oxolane-3-carboxamide
2137740-51-1
2-Cyclopentyl-2-[4-(2,2,2-trifluoroacetyl)piperazin-1-yl]acetic acid
2680658-56-2
Chemsrc provides L-Canavanine sulfate(CAS#:2219-31-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of L-Canavanine sulfate are included as well.>> amp version: L-Canavanine sulfate

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved