Z-Ile-Glu-Thr-Asp-AFC

Modify Date: 2024-01-07 22:24:58

Z-Ile-Glu-Thr-Asp-AFC Structure
Z-Ile-Glu-Thr-Asp-AFC structure
Common Name Z-Ile-Glu-Thr-Asp-AFC
CAS Number 219138-02-0 Molecular Weight 821.75000
Density N/A Boiling Point N/A
Molecular Formula C37H42F3N5O13 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Z-Ile-Glu-Thr-Asp-AFC


Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity[1].

 Names

Name Z-Ile-Glu-Thr-Asp 7-amido-4-trifluoromethylcoumarin
Synonym More Synonyms

 Z-Ile-Glu-Thr-Asp-AFC Biological Activity

Description Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity[1].
Related Catalog
References

[1]. Boudard D, et al. Increased caspase-3 activity in refractory anemias: lack of evidence for Fas pathway implication. Leukemia. 2002;16(11):2343-2345.

 Chemical & Physical Properties

Molecular Formula C37H42F3N5O13
Molecular Weight 821.75000
Exact Mass 821.27300
PSA 279.77000
LogP 3.90270
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles1

More Articles
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro.

J. Biol. Chem. 272 , 13432-13436, (1997)

The apoptotic cysteine protease, caspase-3, is expressed in cells as an inactive 32-kDa precursor from which 17 kDa (p17) and 12 kDa (p12) subunits of the mature caspase-3 are proteolytically generate...

 Synonyms

MFCD01318832
(4S)-5-[[(2S,3R)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoic acid
Cbz-IETD-AFC
Z-Ile-Glu-Thr-Asp-AFC
Z-IETD-AFC