211990-57-7

211990-57-7 structure

Name: Ac-IETD-AFC (N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin)
Chemical Name: 4-[(2-acetamido-3-methylpentanoyl)amino]-5-[[1-[[3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
CAS Number: 211990-57-7
Molecular Formula: C₃₁H₃₈F₃N₅O₁₂
Molecular Weight: 729.65500
Catalog: Research Areas Others
Create Date: 2016-09-09 05:01:15
Modify Date: 2025-08-23 10:42:17
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B[1].

Name	4-[(2-acetamido-3-methylpentanoyl)amino]-5-[[1-[[3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Synonyms	AFC140 Ac-IGTD-AFC Ac-Ile-Glu-Thr-Asp-AFC Ac-Ile-Glu-Thr-Asp-7-Amino-4-trifluoromethylcoumarin

Description	Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. [1]Kazimierz Weglarczyk, et al. Caspase-8 activation precedes alterations of mitochondrial membrane potential during monocyte apoptosis induced by phagocytosis and killing of Staphylococcus aureus. Infect Immun. 2004 May;72(5):2590-7. [2]. Przemysław Reszka, et al. Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substrates. ChemMedChem. 2010 Jan;5(1):103-17.

Precursor 0
DownStream 1
53518-15-3