caspase-8 inhibitor

Modify Date: 2024-01-02 10:37:21

caspase-8 inhibitor structure	Common Name	caspase-8 inhibitor
	CAS Number	191338-86-0	Molecular Weight	502.516
	Density	1.3±0.1 g/cm3	Boiling Point	971.9±65.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₃₄N₄O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	541.6±34.3 °C

Use of caspase-8 inhibitor

Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].

Name	ac-ietd-cho
Synonym	More Synonyms

Description	Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Bajt ML, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 2000 Nov;58(1):109-17. [2]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Bajt ML, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 2000 Nov;58(1):109-17.

[2]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.

Density	1.3±0.1 g/cm3
Boiling Point	971.9±65.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₄N₄O₁₀
Molecular Weight	502.516
Flash Point	541.6±34.3 °C
Exact Mass	502.227478
PSA	228.30000
LogP	-0.55
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.527

WGK Germany	3

ac-ietd-aldehyde

L-Threoninamide, N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-

granzyme b inhibitor (aldehyde)

ac-ile-glu-thr-asp-cho

N-Acetyl-L-isoleucyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-threoninamide

ietd-cho,cell-permeable

ac-ile-glu-thr-asp-h (aldehyde)

granzyme b inhibitor ii

pase-8 inhibitor i

ac-ile-glu-thr-asp-aldehyde

pase 8 inhibitor 1

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: AC-IETD-CHO
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Ac-Ile-Glu-Thr-Asp-aldehyde
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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