BI-2545
Modify Date: 2024-01-06 15:45:36
BI-2545 structure
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Common Name | BI-2545 | ||
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| CAS Number | 2162961-71-7 | Molecular Weight | 527.427 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H19F6N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BI-2545BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively; displays good potency in the LPA and rat whole blood assay (IC50=29 nM); shows substantial lowering of LPA in vivo, and excellent PK/Target Engagement relationship. |
| Name | BI-2545 |
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| Description | BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively; displays good potency in the LPA and rat whole blood assay (IC50=29 nM); shows substantial lowering of LPA in vivo, and excellent PK/Target Engagement relationship. |
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| References | References 1. Christian A. Kuttruff, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1252-1257. DOI: 10.1021/acsmedchemlett.7b00312 View Related Products by Target Autotaxin |
| Molecular Formula | C23H19F6N5O3 |
|---|---|
| Molecular Weight | 527.427 |