BI-2545

Names

[ Name ]:
BI-2545

Biological Activity

[Description]:

BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively; displays good potency in the LPA and rat whole blood assay (IC50=29 nM); shows substantial lowering of LPA in vivo, and excellent PK/Target Engagement relationship.

[References]

References 1. Christian A. Kuttruff, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1252-1257. DOI: 10.1021/acsmedchemlett.7b00312 View Related Products by Target Autotaxin

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₉F₆N₅O₃

[ Molecular Weight ]:
527.427

Related Compounds

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