2162961-71-7
2162961-71-7 structure
- Name: BI-2545
- Chemical Name: BI-2545
- CAS Number: 2162961-71-7
- Molecular Formula: C23H19F6N5O3
- Molecular Weight: 527.427
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2020-01-19 20:27:56
- Modify Date: 2024-01-06 15:45:36
-
BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively; displays good potency in the LPA and rat whole blood assay (IC50=29 nM); shows substantial lowering of LPA in vivo, and excellent PK/Target Engagement relationship.
| Name | BI-2545 |
|---|
| Description | BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively; displays good potency in the LPA and rat whole blood assay (IC50=29 nM); shows substantial lowering of LPA in vivo, and excellent PK/Target Engagement relationship. |
|---|---|
| References | References 1. Christian A. Kuttruff, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1252-1257. DOI: 10.1021/acsmedchemlett.7b00312 View Related Products by Target Autotaxin |
| Molecular Formula | C23H19F6N5O3 |
|---|---|
| Molecular Weight | 527.427 |