HEPARIN, SODIUM, LOW MOLECULAR WEIGHT
Modify Date: 2024-01-09 20:05:51
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT structure
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Common Name | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT | ||
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| CAS Number | 21416-88-6 | Molecular Weight | 282.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H18N4O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of HEPARIN, SODIUM, LOW MOLECULAR WEIGHTICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer[1]. |
| Name | 4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione |
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| Synonym | More Synonyms |
| Description | ICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C12H18N4O4 |
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| Molecular Weight | 282.30 |
| Exact Mass | 282.13300 |
| PSA | 105.80000 |
| Vapour Pressure | 3.48E-11mmHg at 25°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H317 |
| Precautionary Statements | P280-P301 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Risk Phrases | 22-43 |
| Safety Phrases | 36/37 |
| RIDADR | UN 2811 6.1/PG 3 |
| RTECS | TL6380200 |
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DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.
Mutat. Res. 530 , 35-46, (2003) The bis-dioxopiperazine ICRF-193 has long time been considered as a pure topoisomerase II catalytic inhibitor able to exert its inhibitory effect on the enzyme without stabilization of the so-called c... |
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Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs.
Biochem. Pharmacol. 57 , 1105, (1999) As many antitumor drugs can kill tumors through the induction of apoptosis, the effect of these drugs presumably would be enhanced if they were used in combination with other drugs that interact with ... |
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Topoisomerase II poisoning by ICRF-193.
J. Biol. Chem. 276 , 44488-44494, (2001) Antineoplastic bis(dioxopiperazine)s, such as meso-2,3-bis(2,6-dioxopiperazin-4-yl)butane (ICRF-193), are widely believed to be only catalytic inhibitors of topoisomerase II. However, topoisomerase in... |
| meso-4,4'-(3,2-butanediyl)-bis(2,6-piperazinedione) |
| 2,6-Piperazinedione,4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-,rel |
| C12H18N4O4 |
| 2,6-Piperazinedione,4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-,(R*,S*) |
| 2,6-Piperazinedione,4,4'-(1,2-dimethylethylene)di-,meso |
| AjvW2 |
| ICRF-193 |