21416-88-6

21416-88-6 structure

Name: HEPARIN, SODIUM, LOW MOLECULAR WEIGHT
Chemical Name: 4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione
CAS Number: 21416-88-6
Molecular Formula: C₁₂H₁₈N₄O₄
Molecular Weight: 282.30
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2017-08-26 09:27:50
Modify Date: 2025-08-25 10:38:18
ICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer[1].

Name	4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione
Synonyms	meso-4,4'-(3,2-butanediyl)-bis(2,6-piperazinedione) 2,6-Piperazinedione,4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-,rel C12H18N4O4 2,6-Piperazinedione,4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-,(R,S) 2,6-Piperazinedione,4,4'-(1,2-dimethylethylene)di-,meso AjvW2 ICRF-193

Description	ICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
References	[1]. Snapka RM,et al. Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration. Biochem Pharmacol. 1996;52(4):543-549.

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H317
Precautionary Statements	P280-P301 + P310
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Risk Phrases	22-43
Safety Phrases	36/37
RIDADR	UN 2811 6.1/PG 3
RTECS	TL6380200