2'-O-Methyladenosine

Modify Date: 2025-08-24 20:32:22

2'-O-Methyladenosine Structure
2'-O-Methyladenosine structure
 Common Name 2'-O-Methyladenosine
CAS Number 2140-79-6 Molecular Weight 281.268
Density 1.8±0.1 g/cm3 Boiling Point 623.8±65.0 °C at 760 mmHg
Molecular Formula C11H15N5O4 Melting Point 200-202ºC
MSDS USA Flash Point 331.0±34.3 °C

 Use of 2'-O-Methyladenosine


2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities [1][2].

 Names

Name cordysinin B
Synonym More Synonyms

 2'-O-Methyladenosine Biological Activity

Description 2'-O-Methyladenosine, a methylated adenine residue is found in urine of normals as well as in urine of adenosine deaminase (ADA) deficient patients. 2'-O-Methyladenosine exhibits unique hypotensive activities [1][2].
Related Catalog
In Vivo 2'-O-Methyladenosine (100, 200 mg/kg, ip, single dose) exhibits unique hypotensive activities in rats[2]. Animal Model: Male spontaneously hypertensive rats (SHR; 16 weeks old)[2]. Dosage: 100, 200 mg/kg. Administration: IP, single dose. Result: Exhibited a significant hypotensive effect in decreasing blood pressure by about 40-50%.
References

[1]. Hirschhorn R, et al. Increased excretion of modified adenine nucleosides by children with adenosine deaminase deficiency. Pediatr Res. 1982 May;16(5):362-9.

[2]. Yamada T, et al. Naturally occurring 2'-O-methylpurine nucleosides with hypotensive properties. Cell Mol Life Sci. 1998 Feb;54(2):125-8.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 623.8±65.0 °C at 760 mmHg
Melting Point 200-202ºC
Molecular Formula C11H15N5O4
Molecular Weight 281.268
Flash Point 331.0±34.3 °C
Exact Mass 281.112396
PSA 128.54000
LogP -0.15
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.795
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles15

More Articles
Increased excretion of modified adenine nucleosides by children with adenosine deaminase deficiency.

Pediatr. Res. 16(5) , 362-9, (1982)

We have identified seven adenine nucleosides in urines of untreated adenosine deaminase (ADA) deficient patients, four of which (adenosine, 2'-deoxyadenosine, 1-methyladenosine and N6-methyladenosine)...

Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines.

Chem. Biol. 1(1) , 39-45, (1994)

The stability of hybrids of 2'-O-methyl-ribonucleotides with complementary RNA is considerably higher than that of the corresponding DNA.RNA duplexes. The 2'-O-modified ribonucleotides are thus an att...

Effect of PGE2 and of agents that raise cAMP levels on macrophage activation induced by IFN-gamma and TNF-alpha.

J. Leukoc. Biol. 58(2) , 217-24, (1995)

The effect of prostaglandin (PG) E2 on macrophage activation by interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) was evaluated. Murine macrophages infected with Leishmania enri...

 Synonyms

UNII-02YX82IHZ5
2'-O-Methyl adenosine
2'-methyl-adenosine
2'-O-methylAdo
2′-O-Methyladenosine
(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
2'-methoxyadenosine
2'-OMeAdenosine
MFCD00056002
Adenosine, 2'-O-methyl-
2'-O-Methyladenosine
2'-O-Methyl-D-adenosine
(2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol
Adenosine,2'-O-methyl
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