Methyl p-toluenesulfonate

Modify Date: 2024-01-02 09:12:33

Methyl p-toluenesulfonate structure	Common Name	Methyl p-toluenesulfonate
	CAS Number	80-48-8	Molecular Weight	186.228
	Density	1.2±0.1 g/cm3	Boiling Point	291.8±9.0 °C at 760 mmHg
	Molecular Formula	C₈H₁₀O₃S	Melting Point	25-28 °C(lit.)
	MSDS	Chinese USA	Flash Point	130.3±18.7 °C
	Symbol	GHS05, GHS07	Signal Word	Danger

Name	Methyl p-toluenesulfonate
Synonym	More Synonyms

Density	1.2±0.1 g/cm3
Boiling Point	291.8±9.0 °C at 760 mmHg
Melting Point	25-28 °C(lit.)
Molecular Formula	C₈H₁₀O₃S
Molecular Weight	186.228
Flash Point	130.3±18.7 °C
Exact Mass	186.035065
PSA	51.75000
LogP	1.30
Vapour density	6.45 (vs air)
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.517
Storage condition	2-8°C
Water Solubility	Insoluble

Methyl p-toluenesulfonate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT7000000

CHEMICAL NAME :: p-Toluenesulfonic acid, methyl ester

CAS REGISTRY NUMBER :: 80-48-8

BEILSTEIN REFERENCE NO. :: 0609209

LAST UPDATED :: 199707

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C8-H10-O3-S

MOLECULAR WEIGHT :: 186.24

WISWESSER LINE NOTATION :: 1OSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 341 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg/2Y

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg/54W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 11 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 198,73,1988

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H314-H317
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38;R40;R43
Safety Phrases	S26-S36/37/39-S45-S24
RIDADR	UN 3261 8/PG 2
WGK Germany	3
RTECS	XT7000000
Packaging Group	III
Hazard Class	8
HS Code	2904909090

Precursor 9
CAS#:67-56-1 Methanol CAS#:104-15-4 p-Toluenesulfon... CAS#:129624-79-9 (S)-5-methoxyme... CAS#:98-59-9 Tosyl chloride
CAS#:7182-86-7 Tetrabutylammon... CAS#:74-88-4 methyl iodide CAS#:77-78-1 Dimethyl sulfate CAS#:1825-61-2 Trimethyl Metho...
CAS#:79069-32-2 PhI(+)CCPhTsO(-)
DownStream 9
CAS#:109249-29-8 5-ethyl-1-methy... CAS#:10506-59-9 methoxysulfonyl... CAS#:4124-41-8 4-Methylbenzene... CAS#:76443-13-5 (O-methyl disul...
CAS#:76443-14-6 mixed anhydride... CAS#:77-78-1 Dimethyl sulfate CAS#:74-89-5 methylamine CAS#:606-45-1 Methyl 2-methox...
CAS#:57113-89-0 Methyl 2-amino-...

HS Code	2904909090
Summary	HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Rapid and simultaneous determination of sulfonate ester genotoxic impurities in drug substance by liquid chromatography coupled to tandem mass spectrometry: comparison of different ionization modes.

J. Chromatogr. A. 1355 , 73-9, (2014)

Two ionization techniques for liquid chromatography-mass spectrometry (LC-MS) determination of sulfonate ester potentially genotoxic impurities (PGIs) were evaluated. Twelve PGIs including methyl, eth...

Secondary deuterium isotope effects.. beta.-Kinetic effects in Sn2 reactions of N, N-dimethylaniline and dimethylphenylphosphine with methyl p-toluenesulfonate, and comparison with observed and calculated vibrational frequencies. Kaplan ED and Thornton ER.

J. Am. Chem. Soc. 89(25) , 6644-51, (1967)

The formation of tin-nitrogen bonds. V. The selective 1-substitution reaction of tetrazoles by the reaction of 5-substituted 2-(tri-n-butylstannyl) tetrazoles with methyl iodide, methyl p-toluenesulfonate, dimethyl sulfate, and ethyl bromoacetate. Isida T, et al.

Bull. Chem. Soc. Jpn. 46 , 2176-80, (1973)

EINECS 201-283-5

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methyl p-toluene sulfonate

MPTS

PTS1

Methyl p-toluenesulf

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MPTS,TRISODIUM SALT

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MFCD00008417

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METHYL P-TOSYLATE

METHYL TOSYLATE

Methanol tosylate

p-Tolylmethylsulfonate

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Methyl p-toluenesulfonate
Price: ￥168.0/500g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Methyl p-toluenesulfonate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Methyl p-toluenesulfonate
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: P-Toluene sulfonic acid Methyl Ester, PTSM, Methyl p-toluenesulfonate, P-Toluenesulfonic acid Methyl
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Methyl p-toluenesulfonate

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