beta-Amanitin
Modify Date: 2024-01-13 16:37:21
beta-Amanitin structure
|
Common Name | beta-Amanitin | ||
|---|---|---|---|---|
| CAS Number | 21150-22-1 | Molecular Weight | 919.95400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H53N9O15S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of beta-Amanitinβ-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2]. |
| Name | β-AMANITIN |
|---|---|
| Synonym | More Synonyms |
| Description | β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Traditional Cytotoxic Agents |
| In Vitro | β-Amanitin (0.01-100 µg/mL; 36 hours) shows toxicity in MCF-7 cells, and the rates of cell viability are calculated as 52%, 62%, 84%, 86%, and 91% at concentrations of 100, 10, 1, 0.1, and 0.01 µg/mL, respectively[2]. β-Amanitin shows a great inhibition of protein synthesis at both concentrations (10 µg/mL and 1 µg/mL) in MCF-7 cells for 24 hours[2]. Cell Viability Assay[2] Cell Line: MCF-7 cells Concentration: 0.01, 0.1, 1, 10, 100 µg/mL Incubation Time: 36 hours Result: Showed toxicity in MCF-7 cells. |
| References |
[2]. Lutz C, et al. Alpha- and Beta-Amanitin Total Synthesis. Angew Chem Int Ed Engl. 2020 Feb 24. |
| Molecular Formula | C39H53N9O15S |
|---|---|
| Molecular Weight | 919.95400 |
| Exact Mass | 919.33800 |
| PSA | 394.30000 |
| Index of Refraction | 1.695 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H310-H330 |
| Precautionary Statements | P260-P264-P280-P284-P302 + P350-P310 |
| Hazard Codes | T+ |
| Risk Phrases | R26/27/28 |
| Safety Phrases | S7;S28;S45;S36/S37/S39 |
| RIDADR | UN 3462 6.1/PG 1 |
| RTECS | NJ8324000 |
| Hazard Class | 6.1(a) |
|
[Determination of amanitatoxins by HPLC].
Chudoku. Kenkyu. 16(4) , 441-5, (2003) High-performance liquid chromatographic (HPLC) assay has been developed for the simultaneous determination of alpha-amanitin, beta-amanitin and phalloidin in serum. Three toxins were extracted by refl... |
|
|
Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) in toxicological analysis. Studies on the detection of clobenzorex and its metabolites within a systematic toxicological analysis procedure by GC-MS and by immunoassay and studies on the detection of alpha- and beta-amanitin in urine by atmospheric pressure ionization electrospray LC-MS.
J. Chromatogr. B. Biomed. Sci. Appl. 689(1) , 81-9, (1997) GC-MS is the method of choice for toxicological analysis of toxicants volatile in GC while non-volatile and/or thermally labile toxicants need LC-MS for their determination. Studies are presented on t... |
|
|
Validated electrospray liquid chromatographic-mass spectrometric assay for the determination of the mushroom toxins alpha- and beta-amanitin in urine after immunoaffinity extraction.
J. Chromatogr. B. Biomed. Sci. Appl. 748(1) , 125-35, (2000) Specific detection of amanitins in body fluids is necessary for an early diagnosis of an intoxication with amanita mushrooms. In this paper, a liquid chromatographic-mass spectrometric assay after imm... |
| MFCD00151212 |
| 8,20,23,24,27,30,33-octaoxo--dihydroxy-1-methylpropyl)-11-oxide |
| EINECS 244-244-8 |
| B-amanitin from amanita phalloides |
| B-Amanitine |
| ,12,17,18,19,20,21,22,23,23a-octadecahydro-29-sec-butyl-2,14-dihydroxy-21-(2,3 |