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21150-22-1

21150-22-1 structure
21150-22-1 structure
  • Name: beta-Amanitin
  • Chemical Name: β-AMANITIN
  • CAS Number: 21150-22-1
  • Molecular Formula: C39H53N9O15S
  • Molecular Weight: 919.95400
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
  • Create Date: 2018-03-30 08:00:00
  • Modify Date: 2024-01-13 16:37:21
  • β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2].

Name β-AMANITIN
Synonyms MFCD00151212
8,20,23,24,27,30,33-octaoxo--dihydroxy-1-methylpropyl)-11-oxide
EINECS 244-244-8
B-amanitin from amanita phalloides
B-Amanitine
,12,17,18,19,20,21,22,23,23a-octadecahydro-29-sec-butyl-2,14-dihydroxy-21-(2,3
Description β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2].
Related Catalog
Target

Traditional Cytotoxic Agents

In Vitro β-Amanitin (0.01-100 µg/mL; 36 hours) shows toxicity in MCF-7 cells, and the rates of cell viability are calculated as 52%, 62%, 84%, 86%, and 91% at concentrations of 100, 10, 1, 0.1, and 0.01 µg/mL, respectively[2]. β-Amanitin shows a great inhibition of protein synthesis at both concentrations (10 µg/mL and 1 µg/mL) in MCF-7 cells for 24 hours[2]. Cell Viability Assay[2] Cell Line: MCF-7 cells Concentration: 0.01, 0.1, 1, 10, 100 µg/mL Incubation Time: 36 hours Result: Showed toxicity in MCF-7 cells.
References

[1]. Kaya E, et al. Evaluation and comparison of alpha- and beta-amanitin toxicity on MCF-7 cell line. Turk J Med Sci. 2014;44(5):728-32.

[2]. Lutz C, et al. Alpha- and Beta-Amanitin Total Synthesis. Angew Chem Int Ed Engl. 2020 Feb 24.

Molecular Formula C39H53N9O15S
Molecular Weight 919.95400
Exact Mass 919.33800
PSA 394.30000
Index of Refraction 1.695

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ8324000
CAS REGISTRY NUMBER :
21150-22-1
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C39-H53-N9-O15-S
MOLECULAR WEIGHT :
920.07

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 269,223,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,2142,1972
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300-H310-H330
Precautionary Statements P260-P264-P280-P284-P302 + P350-P310
Hazard Codes T+
Risk Phrases R26/27/28
Safety Phrases S7;S28;S45;S36/S37/S39
RIDADR UN 3462 6.1/PG 1
RTECS NJ8324000
Hazard Class 6.1(a)