AT-130
Modify Date: 2023-01-27 14:37:31
AT-130 structure
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Common Name | AT-130 | ||
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| CAS Number | 211364-06-6 | Molecular Weight | 488.338 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H22BrN3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AT-130AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM; inhibits replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro with same sensitivity (rtL180M, rtM204I, and rtL180M + rtM204V); blocks HBV replication at the level of viral RNA packaging, interferes with capsid morphogenesis, shows activity against the main lamivudine- and adefovir-resistant mutants. |
| Name | AT-130 |
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| Description | AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM; inhibits replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro with same sensitivity (rtL180M, rtM204I, and rtL180M + rtM204V); blocks HBV replication at the level of viral RNA packaging, interferes with capsid morphogenesis, shows activity against the main lamivudine- and adefovir-resistant mutants. |
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| References | References 1. Delaney WE 4th, et al. Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60. 2. Feld JJ, et al. Antiviral Res. 2007 Nov;76(2):168-77. 3. Billioud G, et al. Antiviral Res. 2011 Nov;92(2):271-6. View Related Products by Target HBV |
| Molecular Formula | C22H22BrN3O5 |
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| Molecular Weight | 488.338 |
| Hazard Codes | Xi |
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